Publications
Analysis of oligodendrocyte lineage cell progression with Cre-mediated RiboTag reporter lines. Melchor GS, Shah MS, Manavi Z, Rosko LM, Hu J, Wang H, Baydyuk M, Huang JK. ASN Neuro. 2025;17(1):2513885. doi: 10.1080/17590914.2025.2513885. Epub 2025 Jun 13. PubMed PMID: 40515465; PubMed Central PMCID: PMC12169044.
Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelination. Manavi Z, Melchor GS, Bullard MR, Gross PS, Ray S, Gaur P, Baydyuk M, Huang JK. J Neuroinflammation. 2025 Apr 7;22(1):101. doi: 10.1186/s12974-025-03425-3. PubMed PMID: 40197319; PubMed Central PMCID: PMC11974124
Differential Effects of IL4I1 Protein on Lymphocytes From Healthy and Multiple Sclerosis Patients. Davis SE, Hu J, Nanescu SE, Kumar MN, Baydyuk M, Oft HC, Amjad FS, Wellstein A, Huang JK. Pharmacol Res Perspect. 2025 Apr;13(2):e70062. doi: 10.1002/prp2.70062. PubMed PMID: 40102177; PubMed Central PMCID: PMC11919572
Senescent-like microglia limit remyelination through the senescence associated secretory phenotype. Gross PS, Durán-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Fu MM, Schafer DP, Huang JK. Nat Commun. 2025 Mar 7;16(1):2283. doi: 10.1038/s41467-025-57632-w. PMID: 40055369
Intrinsic retinoic acid synthesis is required for oligodendrocyte progenitor expansion during CNS remyelination. Nanescu SE, Wathieu NM, Rosko L, Cha DS, Kumar MN, Olszewski RT, Reger J, Baydyuk M, Dua AN, Krezel W, Zujovic V, Huang JK. Front Cell Neurosci. 2025 Feb 24;19:1550139. doi: 10.3389/fncel.2025.1550139. eCollection 2025. PMID: 40065911
The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination. Gharibani P, Abramson E, Shanmukha S, Smith MD, Godfrey WH, Lee JJ, Hu J, Baydyuk M, Dorion MF, Deng X, Guo Y, Calle AJ, A Hwang S, Huang JK, Calabresi PA, Kornberg MD, Kim PM. Sci Transl Med. 2025 Jan 8;17(780):eadk3434. doi: 10.1126/scitranslmed.adk3434. Epub 2025 Jan 8. PMID: 39772770.
Potential role of solid lipid curcumin particle (SLCP) as estrogen replacement therapy in mitigating TDP-43-related neuropathy in the mouse model of ALS disease. Majumder P, Hsu TI, Hu CJ, Huang JK, Lee YC, Hsieh YC, Ahsan A, Huang CC. Exp Neurol. 2025 Jan;383:114999. doi: 10.1016/j.expneurol.2024.114999. Epub 2024 Oct 16. PMID: 39419433
Dissecting the evolving cellular landscape of a remyelinating microenvironment. Melchor GS, Baydyuk M, Manavi Z, Hu J, Huang JK. bioRxiv [Preprint]. 2024 Dec 25:2024.12.25.630253. doi: 10.1101/2024.12.25.630253. PMID: 39764038
Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration. Hu J, Melchor GS, Ladakis D, Reger J, Kim HW, Chamberlain KA, Shults NV, Oft HC, Smith VN, Rosko LM, Li E, Baydyuk M, Fu MM, Bhargava P, Huang JK. NPJ Regen Med. 2024 Jan 2;9(1):1. doi: 10.1038/s41536-023-00345-9. PMID: 38167866; PMCID: PMC10762216.
The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype. Demby T, Gross PS, Mandelblatt J, Huang JK, Rebeck GW. Exp Neurol. 2024 Jan;371:114609. doi: 10.1016/j.expneurol.2023.114609. Epub 2023 Nov 7. PubMed PMID: 37944881.
Pervasive cortical and white matter anomalies in a mouse model for CHARGE syndrome. Donovan APA, Rosko L, Ellegood J, Redhead Y, Green JBA, Lerch JP, Huang JK, Basson MA. J Anat. 2023 Mar 13;. doi: 10.1111/joa.13856. [Epub ahead of print] PubMed PMID: 36914558.
Pharmacological treatment promoting remyelination enhances motor function after internal capsule demyelination in mice. Yamazaki R, Osanai Y, Kouki T, Huang JK, Ohno N. Neurochem Int. 2023 Mar;164:105505. doi: 10.1016/j.neuint.2023.105505. Epub 2023 Feb 6. PubMed PMID: 36754122.
Cerebral creatine deficiency affects the timing of oligodendrocyte myelination. Rosko LM, Gentile T, Smith VN, Manavi Z, Melchor GS, Hu J, Shults NV, Albanese C, Lee Y, Rodriguez O, Huang JK. J Neurosci. 2023 Feb 15;43(7):1143-1153. doi: 10.1523/JNEUROSCI.2120-21.2022. Epub 2023 Feb 2. PubMed PMID: 36732069; PubMed Central PMCID: PMC9962777.
Making myelin regenerate: Factors to consider. Huang JK, DeSilva TM. Curr Opin Pharmacol. 2023 Feb;68:102326. doi: 10.1016/j.coph.2022.102326. Epub 2022 Dec 10. PubMed PMID: 36512980.
Impact of amino acids on microglial activation and CNS remyelination. Hu J, Baydyuk M, Huang JK. Curr Opin Pharmacol. 2022 Oct;66:102287. doi: 10.1016/j.coph.2022.102287. Epub 2022 Sep 5. PMID: 36067684
The Cellular Senescence Factor Extracellular HMGB1 Directly Inhibits Oligodendrocyte Progenitor Cell Differentiation and Impairs CNS Remyelination. Rouillard ME, Hu J, Sutter PA, Kim HW, Huang JK, Crocker SJ. Front Cell Neurosci. 2022 Apr 28;16:833186. doi: 10.3389/fncel.2022.833186. eCollection 2022. PMID: 35573828
Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A. Creighton BA, Afriyie S, Ajit D, Casingal CR, Voos KM, Reger J, Burch AM, Dyne E, Bay J, Huang JK, Anton ES, Fu MM, Lorenzo DN. eLife. 2021 Nov 23;10:e69815. doi: 10.7554/eLife.69815. PMID: 34812142
Macroscopic detection of demyelinated lesions in mouse PNS with neutral red dye. Yamazaki R, Osanai Y, Kouki T, Shinohara Y, Huang JK, Ohno N. Sci Rep. 2021 Aug 19;11(1):16906. doi: 10.1038/s41598-021-96395-4. PMID: 34413421
Acute motor deficit and subsequent remyelination-associated recovery following internal capsule demyelination in mice. Yamazaki R, Ohno N, Huang JK. J Neurochem. 2020 Aug 4. doi: 10.1111/jnc.15142. Online ahead of print. PMID: 32750162
Extrinsic Factors Driving Oligodendrocyte Lineage Cell Progression in CNS Development and Injury. Baydyuk M, Morrison VE, Gross PS, Huang JK. Neurochem Res. 2020 Jan 29. doi: 10.1007/s11064-020-02967-7. [Epub ahead of print]. Review. PMID: 31997102
Retinoic Acid Is Required for Oligodendrocyte Precursor Cell Production and Differentiation in the Postnatal Mouse Corpus Callosum. Morrison VE, Smith VN, Huang JK. eNeuro. 2020 Jan 22;7(1). pii: ENEURO.0270-19.2019. doi: 10.1523/ENEURO.0270-19.2019. Print 2020 Jan/Feb. PMID: 31879367
Remyelination Pharmacotherapy Investigations Highlight Diverse Mechanisms Underlying Multiple Sclerosis Progression. Melchor GS, Khan T, Reger JF, Huang JK ACS Pharmacol Transl Sci. 2019, 2, 6, 372-386. Review. https://doi.org/10.1021/acsptsci.9b00068
Tracking the evolution of CNS remyelinating lesion in mice with neutral red dye. Baydyuk M, Cha DS, Hu J, Yamazaki R, Miller EM, Smith VN, Kelly KA, Huang JK. Proc Natl Acad Sci U S A. 2019 Jun 24. pii: 201819343. doi: 10.1073/pnas.1819343116. [Epub ahead of print]. PMID: 31235582
Oligodendrocyte Bioenergetics in Health and Disease. Rosko L, Smith VN, Yamazaki R, Huang JK. Neuroscientist. 2019 Aug;25(4):334-343. doi: 10.1177/1073858418793077. Epub 2018 Aug 20. PMID: 30122106
Creatine enhances mitochondrial-mediated oligodendrocyte survival following demyelinating injury. Chamberlain KA, Chapey KS, Nanescu SE, Huang JK. J Neurosci. 2017 Jan 9. pii: 1941-16. doi: 10.1523/JNEUROSCI.1941-16.2016. [Epub ahead of print]. PMID: 28069926
IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation. Psachoulia K, Chamberlain KA, Heo D, Davis SE, Paskus JD, Nanescu SE, Dupree JL, Wynn TA, Huang JK. Brain. 2016 Dec;139(Pt 12):3121-3136. PMID: 27797811
Oligodendrocytes in health and disease. Huang JK, Káradóttir RT. Neuropharmacology. 2016 Nov;110(Pt B):537-538. PMID: 27553122
Surface assembly configurations and packing preferences of fibrinogen mediated by the periodicity and alignment control of block copolymer nanodomains. Xie T, Vora A, Mulcahey PJ, Nanescu SE, Singh M, Choi DS, Huang JK, Liu CC, Sanders DP, Hahm JI. ACS Nano. 2016 Aug 23;10(8):7705-20. PMID: 27462904
Neural stem and progenitor cells in nervous system function and therapy. Walker T, Huang J, Young K. Stem Cells International. 2016; Volume 2016: 1890568. Published online 2016 Aug 14. Editorial. PMCID: PMC4989086
Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation. de la Fuente AG, Errea O, van Wijngaarden P, Gonzalez GA, Kerninon C, Jarjour AA, Lewis HJ, Jones CA, Nait-Oumesmar B, Zhao C, Huang JK, ffrench-Constant C, Franklin RJ. J Cell Biol. 2015 Dec 7;211(5):975-985. PMID: 26644513
Oligodendrocyte regeneration: its significance in myelin replacement and neuroprotection in multiple sclerosis. Chamberlain KA, Nanescu SE, Psachoulia K, Huang JK. Neuropharmacology. 2016 Nov;110(Pt B):633-643. Epub 2015 Oct 22. Review. PMID: 26474658
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration. Moyon S, Dubessy AL, Aigrot MS, Trotter M, Huang JK, Dauphinot L, Potier MC, Kerninon C, Melik Parsadaniantz S, Franklin RJ, Lubetzki C. J Neurosci. 2015 Jan 7;35(1):4-20. PMID: 25568099
Metabolism and mis-metabolism of the neuropathological signature protein TDP-43. Huang CC, Bose JK, Majumder P, Lee KH, Huang JT, Huang JK, Shen CK. J Cell Sci. 2014 Jul 15;127(Pt 14):3024-38. PMID: 24860144
Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination. Syed YA, Baer A, Hofer MP, González GA, Rundle J, Myrta S, Huang JK, Zhao C, Rossner MJ, Trotter MW, Lubec G, Franklin RJ, Kotter MR. EMBO Mol Med. 2013 Dec;5(12):1918-34. PMID: 24293318
Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis. Camacho A, Huang JK, Delint-Ramirez I, Yew Tan C, Fuller M, Lelliott CJ, Vidal-Puig A, Franklin RJ. Eur J Neurosci. 2013 Sep;38(5):2672-83. PMID: 23763823
Current status of myelin replacement therapies in multiple sclerosis. Huang JK, Franklin RJM. Prog Brain Res. 2012; 201:219-31. Review. PMID: 23186717
Accelerated axonal loss following acute CNS demyelination in mice lacking protein tyrosine phosphatase receptor type Z. Huang JK, Ferrari CC, Lafont D, Zhao C, Zaratin P, Greco B, Franklin RJM. Am J Pathol. 2012 Nov;181(5):1518-23. PMID: 22940073
Myelin regeneration in multiple sclerosis - targeting endogenous stem cells. Huang JK, Fancy SPJ, Zhao C, Rowitch DH, ffrench-Constant C, Franklin RJM. Neurotherapeutics. 2011 Oct;8(4):650-8. Review. PMID: 21904791
Retinoid X receptors as a potential avenue for regenerative medicine in multiple sclerosis. Huang JK, Jarjour AA, ffrench-Constant C, Franklin RJ. Expert Rev Neurother. 2011 Apr;11(4):467-8. PMID: 21469916
Regenerative medicine in multiple sclerosis: Identifying pharmacological targets of adult neural stem cell differentiation. Huang JK and Franklin RJM. Neurochem Int. 2011 Sep;59(3):329-32. Review. PMID: 21300122
Retinoid X receptor gamma accelerates CNS remyelination. Huang JK, Jarjour AA, Nait-Oumesmar B, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Baron-Van Evercooren A, Chambon P, ffrench-Constant C, Franklin RJM. Nat Neurosci. 2011 Jan;14(1):45-53. PMID: 21131950
Overcoming remyelination failure in multiple sclerosis and other myelin disorders. Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH, Franklin RJM. Exp Neurol. 2010 Sep;225(1):18-23. Review. PMID: 20044992
A proteome map of axoglial specializations isolated and purified from human central nervous system. Dhaunchak AS, Huang JK, de Faria Jr O, Roth AD, Pedraza L, Antel JP, Bar-Or A, Colman DR. Glia. 2010 Dec;58(16):1949-60. PMID: 20830807
Disposition of axonal Caspr with respect to glial cell membranes: implications for the process of myelination. Pedraza L, Huang JK, Colman D. J Neurosci Res. 2009 Nov 15;87(15):3480-91. PMID: 19170162
BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo. Huang JK, Dorey K, Ishibashi S, Amaya E. BMC Dev Biol. 2007 May 31;7:59. PMID: 17540021
Glial membranes at the CNS node of Ranvier prevents neurite outgrowth. Huang JK, Phillips GR, Roth AD, Pedraza L, Shan WS, Belkaid W, Mi S, Fex-Svenningsen A, Florens L, Yates JR, Colman DR. Science. 2005 Dec 16;310(5755):1813-7. PMID: 16293723
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Phillips GR, Huang JK, Wang Y, Tanaka H, Shapiro L, Zhang W, Shan WS, Arndt K, Frank M, Gordon RE, Gawinowicz MA, Zhao Y, Colman DR. Neuron. 2001 Oct 11;32(1):63-77. PMID: 11604139
Organizing principles of the axoglial apparatus. Pedraza L, Huang JK, Colman DR. Neuron. 2001 May;30(2):335-44. Review. PMID: 11394997
An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction. Tait S, Gunn-Moore F, Collinson JM, Huang J, Lubetzki C, Pedraza L, Sherman DL, Colman DR, Brophy PJ. J Cell Biol. 2000 Aug 7;150(3):657-66. PMID: 10931875
Messenger RNAs for kinesins and dynein are located in neural processes. Gould R, Freund C, Palmer F, Knapp PE, Huang J, Morrison H, Feinstein DL. Biol Bull. 1999 Oct;197(2):259-60. PMID: 10573845
Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelination. Manavi Z, Melchor GS, Bullard MR, Gross PS, Ray S, Gaur P, Baydyuk M, Huang JK. J Neuroinflammation. 2025 Apr 7;22(1):101. doi: 10.1186/s12974-025-03425-3. PubMed PMID: 40197319; PubMed Central PMCID: PMC11974124
Differential Effects of IL4I1 Protein on Lymphocytes From Healthy and Multiple Sclerosis Patients. Davis SE, Hu J, Nanescu SE, Kumar MN, Baydyuk M, Oft HC, Amjad FS, Wellstein A, Huang JK. Pharmacol Res Perspect. 2025 Apr;13(2):e70062. doi: 10.1002/prp2.70062. PubMed PMID: 40102177; PubMed Central PMCID: PMC11919572
Senescent-like microglia limit remyelination through the senescence associated secretory phenotype. Gross PS, Durán-Laforet V, Ho LT, Melchor GS, Zia S, Manavi Z, Barclay WE, Lee SH, Shults N, Selva S, Alvarez E, Plemel JR, Fu MM, Schafer DP, Huang JK. Nat Commun. 2025 Mar 7;16(1):2283. doi: 10.1038/s41467-025-57632-w. PMID: 40055369
Intrinsic retinoic acid synthesis is required for oligodendrocyte progenitor expansion during CNS remyelination. Nanescu SE, Wathieu NM, Rosko L, Cha DS, Kumar MN, Olszewski RT, Reger J, Baydyuk M, Dua AN, Krezel W, Zujovic V, Huang JK. Front Cell Neurosci. 2025 Feb 24;19:1550139. doi: 10.3389/fncel.2025.1550139. eCollection 2025. PMID: 40065911
The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination. Gharibani P, Abramson E, Shanmukha S, Smith MD, Godfrey WH, Lee JJ, Hu J, Baydyuk M, Dorion MF, Deng X, Guo Y, Calle AJ, A Hwang S, Huang JK, Calabresi PA, Kornberg MD, Kim PM. Sci Transl Med. 2025 Jan 8;17(780):eadk3434. doi: 10.1126/scitranslmed.adk3434. Epub 2025 Jan 8. PMID: 39772770.
Potential role of solid lipid curcumin particle (SLCP) as estrogen replacement therapy in mitigating TDP-43-related neuropathy in the mouse model of ALS disease. Majumder P, Hsu TI, Hu CJ, Huang JK, Lee YC, Hsieh YC, Ahsan A, Huang CC. Exp Neurol. 2025 Jan;383:114999. doi: 10.1016/j.expneurol.2024.114999. Epub 2024 Oct 16. PMID: 39419433
Dissecting the evolving cellular landscape of a remyelinating microenvironment. Melchor GS, Baydyuk M, Manavi Z, Hu J, Huang JK. bioRxiv [Preprint]. 2024 Dec 25:2024.12.25.630253. doi: 10.1101/2024.12.25.630253. PMID: 39764038
Myeloid cell-associated aromatic amino acid metabolism facilitates CNS myelin regeneration. Hu J, Melchor GS, Ladakis D, Reger J, Kim HW, Chamberlain KA, Shults NV, Oft HC, Smith VN, Rosko LM, Li E, Baydyuk M, Fu MM, Bhargava P, Huang JK. NPJ Regen Med. 2024 Jan 2;9(1):1. doi: 10.1038/s41536-023-00345-9. PMID: 38167866; PMCID: PMC10762216.
The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype. Demby T, Gross PS, Mandelblatt J, Huang JK, Rebeck GW. Exp Neurol. 2024 Jan;371:114609. doi: 10.1016/j.expneurol.2023.114609. Epub 2023 Nov 7. PubMed PMID: 37944881.
Pervasive cortical and white matter anomalies in a mouse model for CHARGE syndrome. Donovan APA, Rosko L, Ellegood J, Redhead Y, Green JBA, Lerch JP, Huang JK, Basson MA. J Anat. 2023 Mar 13;. doi: 10.1111/joa.13856. [Epub ahead of print] PubMed PMID: 36914558.
Pharmacological treatment promoting remyelination enhances motor function after internal capsule demyelination in mice. Yamazaki R, Osanai Y, Kouki T, Huang JK, Ohno N. Neurochem Int. 2023 Mar;164:105505. doi: 10.1016/j.neuint.2023.105505. Epub 2023 Feb 6. PubMed PMID: 36754122.
Cerebral creatine deficiency affects the timing of oligodendrocyte myelination. Rosko LM, Gentile T, Smith VN, Manavi Z, Melchor GS, Hu J, Shults NV, Albanese C, Lee Y, Rodriguez O, Huang JK. J Neurosci. 2023 Feb 15;43(7):1143-1153. doi: 10.1523/JNEUROSCI.2120-21.2022. Epub 2023 Feb 2. PubMed PMID: 36732069; PubMed Central PMCID: PMC9962777.
Making myelin regenerate: Factors to consider. Huang JK, DeSilva TM. Curr Opin Pharmacol. 2023 Feb;68:102326. doi: 10.1016/j.coph.2022.102326. Epub 2022 Dec 10. PubMed PMID: 36512980.
Impact of amino acids on microglial activation and CNS remyelination. Hu J, Baydyuk M, Huang JK. Curr Opin Pharmacol. 2022 Oct;66:102287. doi: 10.1016/j.coph.2022.102287. Epub 2022 Sep 5. PMID: 36067684
The Cellular Senescence Factor Extracellular HMGB1 Directly Inhibits Oligodendrocyte Progenitor Cell Differentiation and Impairs CNS Remyelination. Rouillard ME, Hu J, Sutter PA, Kim HW, Huang JK, Crocker SJ. Front Cell Neurosci. 2022 Apr 28;16:833186. doi: 10.3389/fncel.2022.833186. eCollection 2022. PMID: 35573828
Giant ankyrin-B mediates transduction of axon guidance and collateral branch pruning factor sema 3A. Creighton BA, Afriyie S, Ajit D, Casingal CR, Voos KM, Reger J, Burch AM, Dyne E, Bay J, Huang JK, Anton ES, Fu MM, Lorenzo DN. eLife. 2021 Nov 23;10:e69815. doi: 10.7554/eLife.69815. PMID: 34812142
Macroscopic detection of demyelinated lesions in mouse PNS with neutral red dye. Yamazaki R, Osanai Y, Kouki T, Shinohara Y, Huang JK, Ohno N. Sci Rep. 2021 Aug 19;11(1):16906. doi: 10.1038/s41598-021-96395-4. PMID: 34413421
Acute motor deficit and subsequent remyelination-associated recovery following internal capsule demyelination in mice. Yamazaki R, Ohno N, Huang JK. J Neurochem. 2020 Aug 4. doi: 10.1111/jnc.15142. Online ahead of print. PMID: 32750162
Extrinsic Factors Driving Oligodendrocyte Lineage Cell Progression in CNS Development and Injury. Baydyuk M, Morrison VE, Gross PS, Huang JK. Neurochem Res. 2020 Jan 29. doi: 10.1007/s11064-020-02967-7. [Epub ahead of print]. Review. PMID: 31997102
Retinoic Acid Is Required for Oligodendrocyte Precursor Cell Production and Differentiation in the Postnatal Mouse Corpus Callosum. Morrison VE, Smith VN, Huang JK. eNeuro. 2020 Jan 22;7(1). pii: ENEURO.0270-19.2019. doi: 10.1523/ENEURO.0270-19.2019. Print 2020 Jan/Feb. PMID: 31879367
Remyelination Pharmacotherapy Investigations Highlight Diverse Mechanisms Underlying Multiple Sclerosis Progression. Melchor GS, Khan T, Reger JF, Huang JK ACS Pharmacol Transl Sci. 2019, 2, 6, 372-386. Review. https://doi.org/10.1021/acsptsci.9b00068
Tracking the evolution of CNS remyelinating lesion in mice with neutral red dye. Baydyuk M, Cha DS, Hu J, Yamazaki R, Miller EM, Smith VN, Kelly KA, Huang JK. Proc Natl Acad Sci U S A. 2019 Jun 24. pii: 201819343. doi: 10.1073/pnas.1819343116. [Epub ahead of print]. PMID: 31235582
Oligodendrocyte Bioenergetics in Health and Disease. Rosko L, Smith VN, Yamazaki R, Huang JK. Neuroscientist. 2019 Aug;25(4):334-343. doi: 10.1177/1073858418793077. Epub 2018 Aug 20. PMID: 30122106
Creatine enhances mitochondrial-mediated oligodendrocyte survival following demyelinating injury. Chamberlain KA, Chapey KS, Nanescu SE, Huang JK. J Neurosci. 2017 Jan 9. pii: 1941-16. doi: 10.1523/JNEUROSCI.1941-16.2016. [Epub ahead of print]. PMID: 28069926
IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation. Psachoulia K, Chamberlain KA, Heo D, Davis SE, Paskus JD, Nanescu SE, Dupree JL, Wynn TA, Huang JK. Brain. 2016 Dec;139(Pt 12):3121-3136. PMID: 27797811
Oligodendrocytes in health and disease. Huang JK, Káradóttir RT. Neuropharmacology. 2016 Nov;110(Pt B):537-538. PMID: 27553122
Surface assembly configurations and packing preferences of fibrinogen mediated by the periodicity and alignment control of block copolymer nanodomains. Xie T, Vora A, Mulcahey PJ, Nanescu SE, Singh M, Choi DS, Huang JK, Liu CC, Sanders DP, Hahm JI. ACS Nano. 2016 Aug 23;10(8):7705-20. PMID: 27462904
Neural stem and progenitor cells in nervous system function and therapy. Walker T, Huang J, Young K. Stem Cells International. 2016; Volume 2016: 1890568. Published online 2016 Aug 14. Editorial. PMCID: PMC4989086
Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation. de la Fuente AG, Errea O, van Wijngaarden P, Gonzalez GA, Kerninon C, Jarjour AA, Lewis HJ, Jones CA, Nait-Oumesmar B, Zhao C, Huang JK, ffrench-Constant C, Franklin RJ. J Cell Biol. 2015 Dec 7;211(5):975-985. PMID: 26644513
Oligodendrocyte regeneration: its significance in myelin replacement and neuroprotection in multiple sclerosis. Chamberlain KA, Nanescu SE, Psachoulia K, Huang JK. Neuropharmacology. 2016 Nov;110(Pt B):633-643. Epub 2015 Oct 22. Review. PMID: 26474658
Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration. Moyon S, Dubessy AL, Aigrot MS, Trotter M, Huang JK, Dauphinot L, Potier MC, Kerninon C, Melik Parsadaniantz S, Franklin RJ, Lubetzki C. J Neurosci. 2015 Jan 7;35(1):4-20. PMID: 25568099
Metabolism and mis-metabolism of the neuropathological signature protein TDP-43. Huang CC, Bose JK, Majumder P, Lee KH, Huang JT, Huang JK, Shen CK. J Cell Sci. 2014 Jul 15;127(Pt 14):3024-38. PMID: 24860144
Inhibition of phosphodiesterase-4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination. Syed YA, Baer A, Hofer MP, González GA, Rundle J, Myrta S, Huang JK, Zhao C, Rossner MJ, Trotter MW, Lubec G, Franklin RJ, Kotter MR. EMBO Mol Med. 2013 Dec;5(12):1918-34. PMID: 24293318
Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis. Camacho A, Huang JK, Delint-Ramirez I, Yew Tan C, Fuller M, Lelliott CJ, Vidal-Puig A, Franklin RJ. Eur J Neurosci. 2013 Sep;38(5):2672-83. PMID: 23763823
Current status of myelin replacement therapies in multiple sclerosis. Huang JK, Franklin RJM. Prog Brain Res. 2012; 201:219-31. Review. PMID: 23186717
Accelerated axonal loss following acute CNS demyelination in mice lacking protein tyrosine phosphatase receptor type Z. Huang JK, Ferrari CC, Lafont D, Zhao C, Zaratin P, Greco B, Franklin RJM. Am J Pathol. 2012 Nov;181(5):1518-23. PMID: 22940073
Myelin regeneration in multiple sclerosis - targeting endogenous stem cells. Huang JK, Fancy SPJ, Zhao C, Rowitch DH, ffrench-Constant C, Franklin RJM. Neurotherapeutics. 2011 Oct;8(4):650-8. Review. PMID: 21904791
Retinoid X receptors as a potential avenue for regenerative medicine in multiple sclerosis. Huang JK, Jarjour AA, ffrench-Constant C, Franklin RJ. Expert Rev Neurother. 2011 Apr;11(4):467-8. PMID: 21469916
Regenerative medicine in multiple sclerosis: Identifying pharmacological targets of adult neural stem cell differentiation. Huang JK and Franklin RJM. Neurochem Int. 2011 Sep;59(3):329-32. Review. PMID: 21300122
Retinoid X receptor gamma accelerates CNS remyelination. Huang JK, Jarjour AA, Nait-Oumesmar B, Kerninon C, Williams A, Krezel W, Kagechika H, Bauer J, Zhao C, Baron-Van Evercooren A, Chambon P, ffrench-Constant C, Franklin RJM. Nat Neurosci. 2011 Jan;14(1):45-53. PMID: 21131950
Overcoming remyelination failure in multiple sclerosis and other myelin disorders. Fancy SP, Kotter MR, Harrington EP, Huang JK, Zhao C, Rowitch DH, Franklin RJM. Exp Neurol. 2010 Sep;225(1):18-23. Review. PMID: 20044992
A proteome map of axoglial specializations isolated and purified from human central nervous system. Dhaunchak AS, Huang JK, de Faria Jr O, Roth AD, Pedraza L, Antel JP, Bar-Or A, Colman DR. Glia. 2010 Dec;58(16):1949-60. PMID: 20830807
Disposition of axonal Caspr with respect to glial cell membranes: implications for the process of myelination. Pedraza L, Huang JK, Colman D. J Neurosci Res. 2009 Nov 15;87(15):3480-91. PMID: 19170162
BDNF promotes target innervation of Xenopus mandibular trigeminal axons in vivo. Huang JK, Dorey K, Ishibashi S, Amaya E. BMC Dev Biol. 2007 May 31;7:59. PMID: 17540021
Glial membranes at the CNS node of Ranvier prevents neurite outgrowth. Huang JK, Phillips GR, Roth AD, Pedraza L, Shan WS, Belkaid W, Mi S, Fex-Svenningsen A, Florens L, Yates JR, Colman DR. Science. 2005 Dec 16;310(5755):1813-7. PMID: 16293723
The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution. Phillips GR, Huang JK, Wang Y, Tanaka H, Shapiro L, Zhang W, Shan WS, Arndt K, Frank M, Gordon RE, Gawinowicz MA, Zhao Y, Colman DR. Neuron. 2001 Oct 11;32(1):63-77. PMID: 11604139
Organizing principles of the axoglial apparatus. Pedraza L, Huang JK, Colman DR. Neuron. 2001 May;30(2):335-44. Review. PMID: 11394997
An oligodendrocyte cell adhesion molecule at the site of assembly of the paranodal axo-glial junction. Tait S, Gunn-Moore F, Collinson JM, Huang J, Lubetzki C, Pedraza L, Sherman DL, Colman DR, Brophy PJ. J Cell Biol. 2000 Aug 7;150(3):657-66. PMID: 10931875
Messenger RNAs for kinesins and dynein are located in neural processes. Gould R, Freund C, Palmer F, Knapp PE, Huang J, Morrison H, Feinstein DL. Biol Bull. 1999 Oct;197(2):259-60. PMID: 10573845